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At 01:27 96-11-04 -0500, you wrote: >At 11:49 03/11/96 -0500, will johnston wrote: > >>I am one of the people taking the experimental drug "ENTACAPONE" produced by >>Orion Pharma of Espoo, Finland - probably to be marketed by Sandoz. >> >>ENTACAPONE is a COMT inhibitor which I understand does not cross the >>blood/brain barrier, but protects the levodopa in Sinemet from attack by >>forces in the torso, much like carbidopa but against a different predator. >> >>I have seen a good bit of traffic among the 'Prammy' users, but about >>nothing from Entacapone users. Are there any other Entacapone users out >there? > >Hello Will, > >I'm not a user yet, but I am going to take part in a drug study using >Tolcapone, which is also a COMT inhibitor, and is expected to be marketed in >the new year. > >The study that I will be involved in is to determine the quantity of the >drug that produces the best results. A Parkinson's specialist mentioned both >Tolcapone and Entacapone in a lecture about new drugs, so they are probably >similar, if not identical. I posted a letter a few days ago asking if anyone knew anything about Tolcapone and received no response. Suraiya's neuro wants to put her on it. The way I understood it is Tolcapone would REPLACE her permax. This was recommeded by her neuro because she was specifically "freezing" a lot (and other symptoms). I did not know this was still an experimental drug. Perhaps Suraiya knew and she is going to be part of a study -- I do not know. Does anyone have any other info on COMT inhibitors? <fontfamily><param>New Berolina</param><bigger>Dr. & Mrs. Sohrab R. Lutchmedial & Deanna M. Bartuccio </bigger></fontfamily><bigger><fontfamily><param>Humanst521 Lt BT</param>email: [log in to unmask] </fontfamily></bigger>