>>I am curious about tremors. It seems that tremors often do not respond to the Eldepryl and Sinemet regime. I have tried different doses of Sinemet and Sinemet CR, no noticeable change in tremor. I do feel better, less inner trembling, and I do sleep better since taking Sinemet. Also, stiffness in right tremor arm is better. Tremor has progressed in 1 year from right foot to right hand. Not able to write much, especially at work under stress. Would really appreciate any input from fellow PWP's with tremor. I will try Amantadine(Symmetrel) next and then Permax. Thank you ! Barbara Jensen 48, PD diagnosed about 2 yrs ago. First noticeable symptom about 5 years ago.<< Barbara, I can only speak for myself but I also find Sinemet doesn't' help with my right arm tremors. I found taking 100mg Amantadine in the morning helps tremendously. Another at night is better yet but I found it interfered with my sleep Joe Young (64-4yrs) --