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Brian asked about evening outthe ups and downs. This was a problem Peter had, taking a Sinemet CR 50/200 every 4 hours around the clock. The peaks and valleys were very noticeable, and the "next" pill took a long time to kick in. We badgered the neuro into letting him try regular Sinemet (so as to reduce the carbidopa, which was excessive.) He prescribed 25/250 again every four hours. No particular change. After a week + we decided to use 1/2 a 25/250 every TWO hours, with a full one about 2 A.M. and this is giving Peter a much smoother "ride". It seems the valleys between the peaks on the CR are too deep and long, and this works for us--but if you make a change in meds, be sure to check first with your neuro. Good luck, Camilla Flintermann,CG for Peter 78/7,Oxford,OH