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Dear Michael and Laura I have been off the list for a while but feel I must put some suggestions forward re the problems that Dorothy is having getting onto Sinemet. Barbara, Brian and Dick gave good advice. There are a few things I would like to to add, things I have learned as a resource person for a support group. The nausea and dizzyness are not uncommon when starting parkinson meds. You should know that levodopa activates the "vomiting center" and it takes time to adjust. Low blood pressure is less common---but LBP on standing is the reason why a good Movement Disorder Clinic takes your BP while lying down and then while standing. The carbidopa in the pill is there to keep you from throwing up -- among other things. However there isn't enough carbidopa in one pill and one must not take more Sinemet. In the USA carbidopa is available by itself and it helps. I suggest that Dorothy give the pill something to land on in her stomach. eg.cereal with milk at breakfast. The food slows down the absorption of the pill something wanted by Dorothy because she is a beginner. This is no time for thinking of reducing protein. Long time PWP have to watch their protein intake because protein messes up the absorption of levodopa into the brain. Dorothy won't be at that stage for years. In Canada a prescription drug called domperidome is used successfully for this nausea. I agree with the suggestion that Dorothy try a quarter tablet a day for week at least a week. Then she could try another quarter tablet at another time of day for a week. When she is comfortable at that level she could increase again. There is no need to rush into anything. I am one of those who stopped taking eldepryl. First I dropped from 2 per day to one. Not much difference in how I felt. After a while I started taking Eldepryl every second day. Felt the same. So my doctor said drop the last and if you feel worse we can start again. But again it may be different for a 'newbie' If the tremor is worse when Dorothy is holding a cup and milder when she is just sitting doing nothing you might not be dealing with pure parkinson's. Tremor is only one of THE symptoms. The others are 1) bent over posture 2) a stiffness in the muscles and joints 3) slowness in walking and getting stuck in chairs 4)tiny writing 5) a stiff face and less blinking of eyes. Two or three of these are usually present as well as tremor. I don't agree that Sinemet lasts only 10 years. I have taken Sinemet for16 years and it is still effective. I know one PWP who started on levodopa when it was still in clinical trials, before Sinemet was on the market. She is still taking Sinemet. Now I am going to stick my neck out. Pro Path is a very good system, I'm sure, but who puts it out? And which Parkinson Med do they make? Lots of scope for more messages <:-)/ Anne Rutherford