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I had my P in May. At first fatigue was not a problem but it became one about July when I cud fall asleep while talking to you or stopping to rest after a short walk. A Spanish internest to whom I went because of this a edema suggested 5000 units B12 100 B1 and B6 EVERY OTHER DAY FOR A MONTH. IT WORKED FOR ME I still take it even now and no side effects and no fatigue. Joyce