Another FYI about a meeting of possible interest. Wendy T. --------------------- Forwarded message: From: [log in to unmask] (envsubset) Sender: [log in to unmask] Reply-to: [log in to unmask] To: [log in to unmask] (Multiple recipients of list) Date: 96-11-18 17:02:27 EST [Federal Register: November 18, 1996 (Volume 61, Number 223)] [Notices] [Page 58698-58699] >From the Federal Register Online via GPO Access [wais.access.gpo.gov] ----------------------------------------------------------------------- DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institute of Environmental Health Sciences; National Toxicology Program (NTP) Board of Scientific Counselors' Meeting; Review of Draft NTP Technical Reports Pursuant to Public Law 92-463, notice is hereby given of the next meeting of the NTP Board of Scientific Counselors' Technical Reports Review Subcommittee on December 11 and 12, 1996, in the Conference Center, Building 101, South Campus, National Institute of Environmental Health Sciences (NIEHS), 111 Alexander Drive, Research Triangle Park, North Carolina. The meeting will begin at 8:30 a.m. both days and is open to the public. The agenda topic is the peer review of draft Technical Reports of long-term toxicology and carcinogenesis studies from the National Toxicology Program. Tentatively scheduled to be peer reviewed on December 11-12 are draft Technical Reports of 10 two-year studies, listed alphabetically, along with supporting information in the attached table. All studies were done using Fischer 344 rats and B6C3F<INF>1 mice. The order of review is given in the far right column of the table. Copies of the draft Reports may be obtained, as available, from: Central Data Management, MD E1-02, P.O. Box 12233, Research Triangle Park, NC 27709 (919/541-3419). Persons wanting to make a formal presentation regarding a particular Technical Report must notify the Executive Secretary by telephone, by FAX, or by mail no later than December 6, 1996, and provide a written copy in advance of the meeting so copies can be made and distributed to all Subcommittee members and staff and make available at the meeting for attendees. Written statements should supplement and may expand on the oral presentation. Oral presentations should be limited to no more than five minutes. The program would welcome receiving toxicology and carcinogenesis information from completed, ongoing, or planned studies by others, as well as current production data, human exposure information, and use patterns for any of the chemicals listed in this announcement. Please contact Central Data Management at the address given above, and they will relay the information to the appropriate staff scientist. The Executive Secretary, Dr. Larry G. Hart, P.O. Box 12233, Research Triangle Park, North Carolina 27709 (telephone 919/541-3971; FAX 919/541-0295) will furnish agenda and a roster of Subcommittee members prior to the meeting. Summary minutes subsequent to the meeting will be available upon request to Central Data Management. Dated: November 11, 1996. Kenneth Olden, Director, National Toxicology Program. Summary Data for Technical Reports Tentatively Scheduled for Review at the Meeting of the Board of Scientific Counselor's Technical Reports Review Subcommittee, December 11-12, 1996 ------------------------------------------------------------------------------ ---------------------------------- Technical report Route exposure Review Chemical CAS No. No. Primary uses levels order ------------------------------------------------------------------------------ ---------------------------------- 3'-AZIDO-3'-deoxythymidine (AZT) TR-469 Pyrimidine Gavage 5% 2 30516-87-1 and. nucleoside analog Methylcellulose): with antiviral Mice only: 0, 30, activity used in 60, OR 120 MG/KG; the treatment of 50/SEX. AIDS (Merck 1989). INTERFERON AD+ AZT (AIDS ................... Used in the Subcutaneous Inj.+ INITIATIVE). experimental Gavage (.5% treatment of AIDS. Methylcellulose): DUAL ROUTES WITH BOTH COMPOUNDS: AZT: 0, 30, 60, OR 120 (GAV) MG/KG; IFN: 500 OR 5000 UNITS 3X/WEEK. CHLOROPRENE 126-99-8.............. TR-467 Monomer for neoprene Inhalation (Air): 4 elastomers; Rats & Mice: 0, industrial rubber 12.8, 32.0, OR 80.0 products; component PPM; 50/SEX/SPECIES/ of laboratory GROUP. adhesives in food packaging. [[Page 58699]] COBALT SULFATE HEPTAHYDRATE 10026- TR-471 Drying agent for Inhalation (Air): 3 24-1. varnishes and inks; Rats & Mice; 0, component of 0.3, 1.0, OR 3.0 MG/ electroplating M3; 50/SEX/SPECIES/ solutions. GROUP. ETHLYBENZENE 100-41-4............. TR-466 Manufacture of Inhalation (Air) 6 synthetic rubber. Rats & Mice: 0, 75, Solvent. Fuel 250, 750 PPM (50/ additive. Chemical SEX/SPECIES/GROUP). intermediate. ISOBUTYRALDEHYDE 78-84-2.......... TR-472 Synthesis of Inhalation (Air) 10 pantothenic acid, Rats & Mice: 0, cellulose esters, 500, 1000, OR 2000 perfumes, flavors, PPM (50/SEX/SPECIES/ and gasoline GROUP). additives. Chemical intermediate. OXAZEPAM 604-75-1................. TR-468 Tranquilizer........ Dosed-Feed (NIH-07): 1 Rats only: 0, 625, 1250, 2500, 5000, OR 10000 PPM; 50/ SEX/GROUP. POLYVINYL ALCOHOL 9002-89-5....... TR-474 PVA film for Intravaginal 8 intravaginal (Deionized Water): administration of Mice only: 25% PVA, spermicides. VEHICLE, UNTREATED; Textile warp sizing 100/GROUP. and finishing, adhesives. Pesticides. Pigment in TV picture tubes. PRIMIDONE (PRIMACLONE) 125-33-7... TR-476 Prophylactic Dosed-Feed (NIH-07 9 management of Mice: 0, 0.03, partial grand mal 0.06, OR 0.13% Rats and psychomotor & Mice: 0, 0.06, seizures that are 0.13, OR 0.25% (50/ refractory to other SEX/SPECIES). antiepileptic drugs. TETRAHYDROFURAN 109-99-9.......... TR-475 Reaction medium for Inhalation (Air) 7 grignard and metal Rats & Mice: 0, hydride reactions. 200, 600, OR 1800 Packaging PPM (50/SEX/SPECIES/ fabrication. GROUP). Solvent for resins and plastics. Chemical intermediate. THEOPHYLLINE 58-55-9.............. TR-473 Diuretic, cardiac Gavage (Corn Oil): 5 stimulant, smooth Rats: 0, 7.5, 25, muscle relaxant, OR 75 MG/KG; 50/ antiasthmatic, GROUP Female Mice: occurs naturally in 0, 7.5, 25, OR 75 tea (Merck 1989). MG/KG; 50/GROUP Male Mice: 0, 15, 50, OR 150 MG/KG; 50/GROUP. ------------------------------------------------------------------------------ ---------------------------------- [FR Doc. 96-29465 Filed 11-15-96; 8:45 am] BILLING CODE 4140-01-M