In a message dated 96-11-26 19:52:39 EST, you write: >Which one causes nausea? He'd like to get rid of that one first. > > Samantha - I should start responding to you directly, since we've had so many messages going back and forth. I have intuited, or ferreted out from between the lines (joke) that you're less than enchanted with your doctors, or the medical profession or whatever, and you seem a kindred spirit - one of my "hot buttons" is doctors who don't listen or who don't know enough or whatever it is. Anyway, I'll tell you what I know about these drugs and let others add their bit, and maybe among all of us you'll have a place to start. 1. Sinemet causes nausea in some people, usually, I think, because of the carbidopa. I know L-dopa without carbidopa causes extreme nausea, but apparently some people can get too much carbidopa. (Did we already have this discussion before?). 2. ARTANE, however, might be the place to start if you want to attack the nausea. The only thing I know about it is from Dick's experience. He was taking Cogentin, which is similar to Artane, and for some reason his doctor decided to switch him. He thought he was dying! Within a few hours of his first dose he was deathly ill - or thought he was - and called me to come home from work. He hadn't missed a day of work in 10 or 15 years by that time, and couldn't believe he felt so sick. By the way - a neurologist (one who fueled my skepticism about neurologists who are not Parkinson's specialists) originally prescribed the Cogentin. Once he started going to Dr. Koller (who IS a PD specialist) at KU Med Center, Dr. Koller discouraged the use of the Cogentin, and indicated without saying outright that it is not a drug of choice for PD. It's usually used to treat tremors brought about by other powerful meds, and can cause confusion, etc. Artane is basically the same thing, I understand. I know there is a difference of opinion among doctors, but I would be interested in knowing if anyone else out there besides Samantha's husband sees a PD specialist who HAS prescribed Artane or Cogentin. Good luck. Margie