Sex activity and PD are related, but the exact reltionship is confused. It is generally thouught that sex drive and performance go down with PD and getting older.. It makes things more difficult anyway. Levodopa has different effrcts on different people, and the amount od ldopa makes a difference. [Sinemet is ldopa + other stuff]. The NURSING 96 DRUG HANDBOOK lists a nursing consideration of Sinemet therapy "excessive and inappropriate sexual activity, priapism." This was seen in AWAKENINGS by Oliver Sacks. A floor nurse friend who was on the floor with the original ldopa trials at the NIH says she was chased about almost constantly by those on high doses of ldopa. A former member of our support group who has cut his Sinemet back to 19 per day (all 25/100's except for 2@50/200 CR's). He is abt 71, had PD for about 20 yrs, is unable to stand alone... A woman (age 28?) who holds herself out as a nurse [not sure of formal credentials as to whether RN or LPN] was helping care for him on a paid basis, providing some respite care for his caregiver spouse. Nurse is suing for sexual harrassment claiming that when being helped to stand he grabbed hold of wrong handles and made verbal advances.... I'm waiting to see how the case comes out. WILL JOHNSTON 4049 OAKLAND SCHOOL ROAD SALISBURY, MD 21804-2716 410-543-0110 Pres A.P.D.A. DelMarVa Chapter