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Hi. I'm not sure I agree with the statement that it is better to take 1/2 of a 25/100 every 2 hours than a whole one every four hours. With a half a pill you get a different peak concentration of the drug in your blood than with a whole pill. In other words, with a whole tablet your blood level goes up higher, so it might relieve the symptoms better. I think you should find the dose that gives you the effect you want (1/2, tablet, whole tablet) then see how long that effect lasts (1.5 hours, 2 hours, 3 hours). Then your schedule is based on that. Does anyone else do it this way? Carol Johnston ARNP