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Here's some info on pramipexoled from a patient who's been taking it for three years: Pramipexole is a dopamine agonist similar to parlodel and permax, only more effective. It is a D2 receptor drug which works as a "helper" to sinemet in advanced patients and as a means of postponing sinemet in recently diagnosed patients. In my case, I especially noticed an improvement in balance and handwriting. I recently increased my dosage from .75 to l mg., and noted an improvement in my response to sinemet. It now lasts most of the night, whereas it used to wear off in two hours. (I take the CR/s 25/100). I get a better response during the day, too. The Cr's used to wear off in less than two hours, whereas now I can get two hours from them if I don't eat too much. Let me know if you have any other questions. Pat Schark pine`