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I tried to reply to you directly but couldn't. Thanks for your advice on my sinemet dose. I do take 1/2 25/100 every two or three hours depending on how I'm doing. It seems like I'm always popping pills but this seems to work best for me. What do you think about taking 1/2 the 10/100 instead? I've tried to get into your program at Ron Vetters website but haven't had any luck. Any suggestions? Thanks, Debby Hurlbert [log in to unmask]