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Brian Collins wrote:
>
> On Sat 30 Nov, Joao Paulo Carvalho wrote:
> > Brian Collins wrote:
> >
> > > Incidentally, I used to play Badminton in the earlier days of my PD, and
> > > I too used to take a 'Booster tablet' thinking that I needed it. I now am
> > > sure that in fact this is not so. The dopamine is a neural transmitter:
> > > it passes on messages alomg the chain of neurons carrying the message
> > > from the brain to the muscle. THe same amount of Dopamine is required to
> > > make the arm move gently or move forcefully. However, it was most
> > > important that I did not become underdosed while leaping about, because
> > > I knew that I could not play effectively in that condition. The extra
> > > tablet was effectively an extra bit of insurance.
> > > Regards
> >
> > Brian it may be just a false feeling but seems to me that when I take
> > levedopa and go to play soccer early in the morning the effect of it is
> > a better ? absorption of the drug.This is one thing that has aroused
> > suspection to me anyway.
> >
> > All the best to you
> >
> >    +----| Joao Paulo de Carvalho   |------ +
> >    |         [log in to unmask]     |
> >    +--------| Salvador-Bahia-Brazil |------+
> >
> >
> Hello Joao Paulo, nice to hear from you again. You raise a good point: The
> fact that you are running and expending a lot of energy will certainly
> cause an increase in the rate of flow of blood around the body. The
> levodopa will thus be transportd to the brain more quickly, so that the
> apparrent effect will be like a bigger tablet, but one with a reduced
> effective duration. At a guess, I would suspect that the size of the
> effect would be related to the pulse rate. So, our athlete is going to get
> a boost of levodopa with a reduced time duration. Since most PWP who
> engage in highly energetic activities tend to be those who are in the early
> stage of the disease, they are unlikely to notice the overdose effect.( As
> illustrated in my chart which was discussed a few weeks ago), so we are
> left with the reduced duration. - Perhaps the sportsman should just
> increase the rate of tablets, rather than the size of dose.

Perhaps the rate and the amount ?

Cheers,
--
   +----| Joao Paulo de Carvalho   |------ +
   |         [log in to unmask]     |
   +--------| Salvador-Bahia-Brazil |------+