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Subject: Search for PD Gene For Mark and Tammy Gargano The message attached to this post was a direct appeal from the team who have announced that they are close to finding a Gene which can cause PD. They ask for more potential members of the original Italian family, and it seems that your family may be part of that group. If so, it could shorten the time to find the precise gene considerably. Could I ask you to check through Dr. Golbe's email (attached) and either get in touh with him, or f you wish, I will do it for you. Either way, please let me know what you decide. It is VERY IMPORTANT Regards, Brian Collins ************************************************************** > This article submitted by Lawrence I. Golbe, MD on 11/23/96. > > Author's Email: [log in to unmask] > > I am a research neurologist specializing in PD at the University of > Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical > School, New Brunswick, NJ. On Nov. 15, my colleagues and I announced > that we found the general location of a gene causing PD in a large > Italian-American family in which 60 people have had PD over the past 4 > generations. The laboratory analysis was able to use only 9 of the > affected individuals, as the others were deceased. This allowed us to > narrow the location of the gene to an area of chromosome 4 where there > are about 100 known genes and undoubtedly many unknown ones. To find > the exact location of the gene, we need to find more people who, as > (perhaps unwitting) members of the same extended family, may have the > same gene. The family we worked with originated in a town called > Contursi, which is southeast of Naples and due west of Salerno, in > Salerno province of the Campagna region. WE INVITE ANYONE OF ITALIAN > ANCESTRY WHOSE FAMILY INCLUDES AT LEAST TWO PEOPLE WITH PD TO CONTACT > US. You may be able to help us find a gene that causes PD not just in > your family, but possibly in many others, too. Understanding how this > gene works may eventually lead to a powerful new way to treat PD. You > may e-mail me at [log in to unmask], call (908)235-7729, fax > (908)235-7041 or write to me at Department of Neurology, UMDNJ-Robert > Wood Johnson Medical School, New Brunswick, NJ 08903. > -- Brian Collins <[log in to unmask]>