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Jon-
I believe regular sinement should be taken 30 mins before a meal, and
preferably a meal with little protein. With CR it does not make any
difference. You might try taking 1/2 dose more often; it may smooth out your
symptons. I also take 1/2 25/100 with 1/2 cr 50/200 twice a day and 1/2
25/100 when I feel it is needed.
Dick Swindler (52/15)