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Brian Collins wrote: Dear Brian: I think you did an excellent on the charts and I would like to take them to our support group as an example. I can normally Hilite selectivly and save mail on my hard disk. Since your graphs are probably in graphics I am unable to capture the graphs. I have win. 3.1 and word 6.0 which I thought should handle it. Do you or any body have any suggestions. Thanks Henry Guttentag ([log in to unmask]) ++++++++++++++++++++++++++++++++++++++++++++++= > > On Fri 29 Nov, James Johnston wrote: > > Hi. I'm not sure I agree with the statement that it is better to take > > 1/2 of a 25/100 every 2 hours than a whole one every four hours. > > With a half a pill you get a different peak concentration of the drug in > > your blood than with a whole pill. In other words, with a whole tablet > > your blood level goes up higher, so it might relieve the symptoms > > better. I think you should find the dose that gives you the effect you > > want (1/2, tablet, whole tablet) then see how long that effect lasts > > (1.5 hours, 2 hours, 3 hours). Then your schedule is based on that. Does > > anyone else do it this way? Carol Johnston ARNP > > > > > Somehow, I knew that I wouldn't get away with my rather generalised example. > The point which I was trying to make is that If you take a tablet with an > effective life of about 2 hours (e.g. Sinemet) once every 4 hours, you are > going to have 2 hours over or under-medicated, depending on your particular > requirements, followed by 2 hours of no medication. (= misery) > > I have gone into the concept of 'Peak Concentration' in some detail (As Ron > Vetter will recall) and I think it has little relevance to what happens when > the Levodopa actually reaches the brain. However that is another (large) > subject for another time. > > I would not dream of working out my dosage regime in this way, as there are > such a lot of variables to account for, so I wrote a computer program to help. > If you would like to see a description of the program, and how to prepare > input for it, take a look at the URL given below ( This page is part of Ron > Vetters Web site, which he generously made available for me to use for the > program description. > > http://www.ridgecrest.ca.us/~rfvetter/brianspd.html > > If you get no response, split the URL in two: > > Go to http://www.ridgecrest.ca.us/ - This gets you into the site. > > Then go to ~rfvetter/brianspd.html This finds my page. > > Regards, > -- > Brian Collins <[log in to unmask]>