Help, I feel like a blindfolded guineu pig! I have just signed on to the first stage of an experiment with a drug called Tolcopone and I would be very greatful for any info on this drug. I know it has been successfully administered to about 800 people in doses up to 800 mg,. I am also aware of some potential side-effects such as diarrhea, headaches, dizziness and nausea. This first stage is just a daily diary to see if I am suitable for the experiment. It's a " double-blind (as in "blindfolded guinea pig!"), randomized, crossover study in patients treated with Prolopa or Senemet who exibit end of dose wearing off." I accepted the role of gineau pig because I trust my neuro, it sounds like an ideal drug for me, and most of all, because I'm desperate. My offs have become more frequent , longer , and more intense recently, and this seemed like a ray of hope in this dark tunnel we call Parkinson's. The study is being carried out by Hoffman-LaRoche and medical staff with 150 patients in 20 sites accross Canada. The purpose is to find out how effective this drug is in prolonging the effects of Senemet. Sounds good to me, but I have this nagging doubt: If it's so good, why has it never shown up her on the network? Or has it ? What am I getting into? Any info would be appreciated. Brian Black