Milton E McLain <[log in to unmask]> wrote <<<<PD Status: 1st symptoms - 1989; diagnosed - 1993; currently Stage I Medications: Eldepryl, 5 mg/day; Artane, 2 mg/ 4 times a day (just discontinued); Permax, 0.25 mg/ 3 times a day Main Complaints: Tremor right arm/hand; makes writing difficult; right leg gait affected, no tremor there. QUESTION: My doctor recently switched me off Artane and on to Permax (pergolide). This was about a month ago. At this point, I am less than thrilled with the results. The tremor is not improved - may even be worse. Also, I seem to be experiencing a "slowness of movement" since beginning Permax that was not there before. Any comments from you out there?>>> my opinion is that you are not taking the best medicine - levodopa. Suggest to your doctor half a 25/100 carbidopa/levodopa 3 times a day half an hour before meals - take with small amount of low protein food; A prune or handfull of cheerios and bran, or a few plain crackers. -- ron 1936, dz PD 1984 Ridgecrest, California Ronald F. Vetter <[log in to unmask]> http://www.ridgecrest.ca.us/~rfvetter