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On Sat, 14 Dec 1996 18:51:05 -0500 Brian Collins <[log in to unmask]> writes: >Hello Jon. I read your post on changing to Sinemet CR tablets with >great >interest, as I was diagnosed as having PD at the age of 39. (That's 17 >years >ago). > You say that the nausea and weakness lasted about 2 hours after >taking the >old tablets: 2 hours is about the duration of effectiveness of the >25/100 >tablet, in most people. Similarly, the CR tablets have a typical >duration of >4 hours, or 50 mg/hr, so on the face of it, nothing much has changed. >I am >inclined to agree with the nurse, that somehow you were taking the >Sinemet >on board too quickly; this was throwing you into an overdose >condition, which >could quite easily last two hours. How frequently were you taking the >25/100 >tablets, and how frequently do you take the CR tablets? > Another rather strange item is the overdose symptoms that resulted. >I have >to continually remind myself that we all differ in various ways in our >response >to PD and the meds which we take for it. > I had no idea where my musings would lead when I started writing >this email. >In the end, I feel that I have contributed very little, but I'll post >it >anyway, and if you have any developments perhaps you will keep us >informed. > >I must comment on the mention of surgery: To someone as young as you >it seems >to me that surgery should be the last thing on your mind. Even though >it was >mentioned for 'in the future' I still find it strange. I won't go into >it in >detail at this point, but let's say that I consider it as a last >resort, and >I'm not there yet. > >I wish you the best of luck, >Regards, >-- >Brian Collins <[log in to unmask]> > Hi Brian I've read most all of your posts with interest and learned quite a bit from others posting too. The neuro had me on the Sinemet 25/100 2x a day. He also has me on the Sinemet 50/200 CR 2x a day. It seems to me that the CR is lasting about 5-6 hrs before I notice the tremors reappearing and I have a decent amount of energy to get my work done. But like you said everyone is different in the way they react to meds. My wife can hardly take a childs dose of some meds w/o reacting rather funny to the meds. In the few days I've taken the CR I've found that I have to take the second one 6-7 hrs after the first or I get the same tired feeling that I got with the 25/100, but without the upset - nauseated feeling. As far as surgury goes I was rather suprised to when the Dr. mentioned it. Maybe he was just letting me know about the options for later down the road. Thanks for the info Jon Meyer 39/1 ([log in to unmask]) another Hoosier