I just sent the email printed below, and received an email from LISTSERV saying that posting of this message was rejected because it had already been sent by me or someone else. This was the first time I tried to send it, so I am trying one more time. Please excuse if for some reason you get it more than once. Mary McCormick Hi Folks, I'm brand new to this List, and have just received the Algorithm for Managing Parkinson's Disease and the Caregiver's Handbook, and have perused a few days' worth of email messages. I'm a caregiver for my sweetie Mike, who is 56 and has had Parkinson's for 15 years. (I'm sending this message for him and at his request.) He's been on Sinemet since the beginning, and is now on a pill schedule of Sinemet and Permax. In May, his Parkinson's doc observed that his dyskinesias were getting rather severe, and suggested that the Sinemet was maybe now causing more trouble than it's benefit. He recommended a gradual changeover to a schedule of Permax and Amantidine. Mike is apprehensive about quitting the Sinemet, since he believes that it is what enables him to move, so he has not made the change. The doctor renewed his recommendation in August. He doesn't say much about what Mike might anticipate experiencing on the new pill schedule, apart from acknowledging that he might be slower. Does anybody out there have any real-life experience on Amantidine, or the combination of Permax and Amantidine? It would be helpful to have more information on which Mike can make his decision. Cheers, Mary ****************************** McCormick International Mary K. McCormick 10808 Glen Wilding Lane Bloomington, Minnesota 55431 U.S.A. Tel.: (612) 884-6408 Fax: (612) 948-0658 Email: [log in to unmask] [log in to unmask]