RE: inquiry about PDand depression, 2 comments-- Peter was on Prozac for some 3 years, and while it did seem to lighten his mood, there was no dramatic change. At our latest neuro visit we asked about changing to Zoloft, and are in the process of phasing it in, some 4 days now. We were told the Prozac could be stopped and the Zoloft started at once because they are in "the same family of drugs", as is Paxil. Also, there is much about depression in the list archives. You can send this message to our "archive angel" John Cottingham: [log in to unmask] "archive search" in subject line, then say what you are looking for. Some of this might be helpful, but as with any other PD meds, its "different strokes for different folks", and reactions vary widely. Good luck! Camilla Flintermann,CG for Peter,78/7.Ohio [log in to unmask]