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On Sat 14 Dec, JON A MEYER wrote: > Greetings to all > > After trying all of the suggestions I got, on when & with what to take > Sinemet with, I still had problems with nausea and a general weakness > lasting about 2 hrs. after taking my meds. > I finally called my neuro Thursday and talked to the nurse (the Dr was > out that day) and she got a hold of the Dr. and he changed me from > sinemet 25/100 to 50/200CR. Low and behold no more nausea or tired > feeling. The nurse told me that the med was hitting my system all at once > and that the CR should help. It seems to be controlling my tremors too. > I also found out that my mother, and my neuro's mother, and my family > Dr's father all went to college together. > > At my last visit the neuro also brought up surgery for in the future. > His suggestions were Loma Linda University Med Center or Indiana Univ. > hospital. I'll wait to see how things progress. > > > Jon Meyer 39/1 ([log in to unmask]) > another Hoosier > (I'm still sticking to the theory of Hoosiers coming from "who's yar") > Hello Jon. I read your post on changing to Sinemet CR tablets with great interest, as I was diagnosed as having PD at the age of 39. (That's 17 years ago). You say that the nausea and weakness lasted about 2 hours after taking the old tablets: 2 hours is about the duration of effectiveness of the 25/100 tablet, in most people. Similarly, the CR tablets have a typical duration of 4 hours, or 50 mg/hr, so on the face of it, nothing much has changed. I am inclined to agree with the nurse, that somehow you were taking the Sinemet on board too quickly; this was throwing you into an overdose condition, which could quite easily last two hours. How frequently were you taking the 25/100 tablets, and how frequently do you take the CR tablets? Another rather strange item is the overdose symptoms that resulted. I have to continually remind myself that we all differ in various ways in our response to PD and the meds which we take for it. I had no idea where my musings would lead when I started writing this email. In the end, I feel that I have contributed very little, but I'll post it anyway, and if you have any developments perhaps you will keep us informed. I must comment on the mention of surgery: To someone as young as you it seems to me that surgery should be the last thing on your mind. Even though it was mentioned for 'in the future' I still find it strange. I won't go into it in detail at this point, but let's say that I consider it as a last resort, and I'm not there yet. I wish you the best of luck, Regards, -- Brian Collins <[log in to unmask]>