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11-Dec-96 Recognizing Nonmotor "Off" Symptoms In Parkinson's
Patients: Way To Avoid Unnecessary Treatments
Recognizing Nonmotor "Off" Symptoms In Parkinson's Patients: Way
To Avoid Unnecessary Treatments
WESTPORT, Dec 11 (Reuters) - Recognition of nonmotor "off"
phenomena in Parkinson's disease patients can prevent unnecessary
tests and treatments, two researchers at the University of
Medicine and Dentistry of New Jersey, New Brunswick, report.
Drs. Jacob I. Sage and Machteld E. Hillen studied 130 patients
with Parkinson's disease and motor fluctuations.
Dr. Sage told Reuters Health: "Most physicians who think of
fluctuations in Parkinson's disease patients think of motor
fluctuations. An important thing to realize is that there are
nonmotor fluctuations that may be just as disabling. This is not
an uncommon problem. Among patients who have motor fluctuations,
17% have nonmotor fluctuations, as well, [such as]
cognitive/psychiatric dysfunction, sensory symptoms and autonomic
dysfunction, which can occur as end-of-dose phenomena."
More specifically, nonmotor "off" states, according to Drs. Sage
and Hillen, are manifested as "...sensory dyspnea, nausea, facial
flushing, cough, hunger, unilateral limb edema, proximal limb
pain, and trigeminal neuralgia-like pain."
The authors recommend diminishing the amount of "off" time as
much as possible. To that end, "...[a]dding a dopamine agonist,
using controlled-release preparations of [levodopa], or
increasing the frequency of dopaminergic medication may be
helpful [in] some of these patients."
Neurology 1996;47:1180-1183.
-Westport Newsroom 203 221 7648
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Copyright c 1996 Reuters Limited.
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Copyright c 1996 Reuters Limited.
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