It was mentioned on the list that some PWP also run the risk of
suffering from Alzheimers. I did a search of MedNet at Reuters and
came up with a large number of articles on the subject ( samples
shown below ) To log onto MedNet go to
http://www.reutershealth.com/news/index.html/
You will have to fill out an information sheet but access is free
after that. Use the advanced search options and enter your query.
Abnormal Glutamate Transport Linked To Alzheimer Neurodegeneration
WESTPORT, Dec 17 (Reuters) - In patients with Alzheimer's
disease, decreased glutamate transporter activity might be
involved in the pathogenesis of synaptic damage.
Dr. E. Masliah at the University of California, San Diego,
explains in Annals of Neurology, "Deficient functioning of
glutamate transporters might be involved in synaptic pathology
and neurodegeneration [in Alzheimer's disease] by failing to
clear excess glutamate at the synaptic cleft."
Dr. Masliah and colleagues studied the brains of 16 people known
to have had Alzheimer's disease and 7 age-matched controls who
were "clinically and histopathologically free of neurological
disease." The researchers assessed glutamate transporter activity
by measurements of D- and L- [3H]aspartate binding. In addition,
they measured synaptic loss by analyzing immunoreactivity of
synaptophysin, "...an abundant small synaptic vesicle
protein...levels of which have been used as an indicator of
synaptic content in the nervous system."
Dr. Masliah reports, "Compared to control brains, [Alzheimer's
disease] brains displayed a 34% decrease in levels of
D-[3H]aspartate binding, a 30% decrease in L-[3H]aspartate
binding, and a 48% loss of synaptophysin immunoreactivity.
Increased levels of brain spectrin degradation products
correlated with a decrease in levels of D-[3H] and
L-[3H]aspartate binding, and decreased levels of synaptophysin
immunoreactivity. Levels of L-[3H]aspartate binding correlated
with levels of synaptophysin immunoreactivity."
The researchers write that L-[3H]aspartate uptake correlated also
with the results of psychometric tests administered before death,
"...indicating that damage to glutaminergic terminals plays an
important role in cognitive dysfunction in [Alzheimer's
disease]."
They add, "As to the identify of the glutamate transporter
responsible for the decrease [in] D- and L-[3H] aspartate uptake,
future studies with antibodies that recognize specific glutamate
transporters will be necessary to help clarify this issue."
Ann Neurol 1996;40:759-766.
Search Results:
Legend: Medical News -- Health eLine --
20-Dec-96 Occupational Electromagnetic Field Exposure Appears
To Increase Risk Of Alzheimer's
19-Dec-96 Alzheimer's Risk On The Job
18-Dec-96 Alzheimer's Blood Test Closer
18-Dec-96 ApoE e4 Allele Linked To Risk Of Dementia In Down's
Syndrome Patients
17-Dec-96 Abnormal Glutamate Transport Linked
To Alzheimer Neurodegeneration
12-Dec-96 Polyglutamine Peptides Linked To CNS Disorders Form Aggregates
11-Dec-96 Drugs Approved Quicker In U.S.
10-Dec-96 Fortune Calls Three Healthcare Industries 'Hot' For 1997
09-Dec-96 Cell Defect Linked To Alzheimer's
06-Dec-96 Dementia And The Elderly
06-Dec-96 Alzheimer-Related Presenilin 2 Mutation Enhances Apoptosis
06-Dec-96 Signal Pharmaceutical Licenses Signaling Proteins From University Of
Massachusetts
05-Dec-96 Cephalon To File For FDA Okay of Narcolepsy Drug By
Year's End
05-Dec-96 APOE Genotyping May Be Useful For Dementia Management
04-Dec-96 Caring For The Caregiver Pays
04-Dec-96 Care For Caregivers Delays Nursing Home Placement Of
Alzheimer's Patients
29-Nov-96 Biochemical Similarities Between Alzheimer Disease and Down Syndrome
Described
27-Nov-96 FDA OKs New Dementia Drug
27-Nov-96 FDA Approves Second Alzheimer's Drug
27-Nov-96 Genentech, CytoTherapeutics To Collaborate On CNS Diseases
20-Nov-96 Olfactory Pathways Create 'Odor Images'
20-Nov-96 Mouse Model Mimics Down Syndrome-Related Alzheimer Disease
19-Nov-96 New Guidelines Established For Postmortem Alzheimer's Diagnosis
19-Nov-96 Cortex Stock Soars On Study Results
19-Nov-96 Vertex Compound Accelerates Nerve Regeneration In Rat Model
19-Nov-96 Cephalon, Leo To Develop Neurologic Diseases Treatments
18-Nov-96 Nicotine-like Drug Shows "Impressive" Effects On Memory
18-Nov-96 Systemic Inflammation Induces Nitric Oxide Synthase In Brain
18-Nov-96 New Drug Shows promise In Treatment Of Alzheimer's Disease
15-Nov-96 HIV Protein Shown To Inhibit Growth Hormone Secretion
14-Nov-96 Gene Testing Guidelines Released
14-Nov-96 Antibody Binding Higher In Alzheimer's
14-Nov-96 Eye Drop Test Unreliable Indicator Of Alzheimer's Disease
12-Nov-96 Alzheimer's Disease May Present With Biparietal Atrophy
07-Nov-96 Link Between Alzheimer's And Autochthonous IgM On T
Cells Noted
05-Nov-96 Research Update From Nature Genetics
04-Nov-96 Products Of Three "Crucial" Alzheimer's Genes Exhibit
Specific Binding
30-Oct-96 Protein Signals Alzheimer's
30-Oct-96 Protein p97: Potential Serum Marker For Alzheimer's
Disease
29-Oct-96 Estrogen Benefits Brain And Bone
28-Oct-96 Birth Rates Decline, Deaths Inch Up
28-Oct-96 Estrogen Replacement Therapy May Lower Risk of Alzheimer's Disease
24-Oct-96 Mutant Presenilin 1 Gene Linked To Alzheimer's-Related Plaque
24-Oct-96 Nicotine May Have Double-Pronged Benefit In Alzheimer's Disease
24-Oct-96 Nicotine-Memory Link Found
22-Oct-96 Eli Lilly And Neurocrine Biosciences To Develop Obesity, Alzheimer's Compounds
16-Oct-96 Cherokees Resistant To Alzheimer's
15-Oct-96 Pure Ancestry, Mixed Ancestry Influence Risk For Alzheimer's In Cherokee
Indians
15-Oct-96 Early Diagnosis Of Lyme Meningitis: Highlight Of American Neurological
Association Meeting
15-Oct-96 Weight Loss May Predict Alzheimer's
14-Oct-96 Weight Loss May Predict Alzheimer's
14-Oct-96 Weight Loss In Alzheimer's Patients: New Observations Reported
10-Oct-96 Glycosaminoglycans May Have Key Role In Alzheimer's "Tangles"
07-Oct-96 Mice Given Alzheimer's Disease
07-Oct-96 Alzheimer's Disease Neurofibrillary Tangles Inhibited
In Vitro
04-Oct-96 New Mouse Model For Alzheimer's Disease Developed
04-Oct-96 Differential Diagnosis Of Dementia and Delirium Essential
01-Oct-96 New Guidelines For Alzheimer's Diagnosis
27-Sep-96 HHS Issues New Guidelines For Alzheimer's Disease, Other Dementias
26-Sep-96 New Test For Mad Cow Disease
26-Sep-96 Eisai Receives Approvable Letter On Alzheimer Agent
25-Sep-96 Cultural Environment May Affect Alzheimer Disease Prevalence
25-Sep-96 U.S. Lifestyle May Up Alzheimer's Risk
12-Sep-96 "Alzheimer's Gene" May Be Inadequate Antioxidant
09-Sep-96 Don't Forget Aspirin! 06-Sep-96 School HIV Prevention
Programs Need Improvement
06-Sep-96 Aspirin Use May Decrease Risk For Alzheimer's
06-Sep-96 Photocopiers Are An Occupational Hazard
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