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Brenda, I also had a bumpy first experience with SINEMET, but I am quite reluctant to give you any kind of advice, because I think the responsibility and the risk have to be taken by a doctor. Doctors may be wrong, or away for vacations, but medical diagnosis and prescription are part of their job. PD patients or caregivers, cannot take into account such things as side effects, interaction between drugs, etc... I don't even tell you the kind of SINEMET I am taking, nor the number of pills, just because I am not sure they are counted the same way in my country and in yours. Other inputs from the group would be appreciated. Bernard JOLY [log in to unmask]