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Brian=8A I do not have time to reply to many letters, but I could not let yours go by. I just want to say that I don't speak for others on the list, but in my humble opinion, your letters ( though somewhat verbose at times as you suggest!) are absolutely invaluable to "newbies" like me (6 years on meds). When I see your name , I always read the letter. Thanks for the tremendous contribution and advice you have given; As usual, your letter is right on! PS : I would like to try your computer programe when my Tolcapone experiment is over. I'm in my second week as part of a test group, taking 1 Tolcapone , 1 Eldepryll, 3 Senemet CR 200/50, and 3 permax .25 daily. So far ,so good! Cheers, Brian Black, Simcoe, Ont , Canada.