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10/13/95 Neurosciences Institute, Good samaritan hospital, LA this is only a part of the abstract of the study conducted under Oleg V. Kopyov, et al. The complete article can be found in Cell Transplantation, Vol 5, No 2, pp. 327-337, 1996 if you can't find the original study please sent me your snail address and i will send you the copy of this and few other recent studies. Abstract This study reports our findings from 22 patients (ages ranging from 42 to 73 yr; mean=55.2) with recalicrant idiopathic PD who received implants of fetal ventral mesencephalic tissue using an MRI-guided stereotactic procedure and who have been followed for at least 6 mo postoperatively, employing the guidelines established by the Core Assessment Program for Intracerebral Transplantations. Evaluations were videotaped and were performed both on and off levedopa medications. To date, we have seven patients with 24 mo, three with 18 mo, three with 12 mo, and nine with 6 mo of post-surgical assessments. Comparing surgical outcomes to levels prior to fetal transplants we found: 1) mean levedopa levels were reduced 46% at 6 mo, 12% at 12 mo, 20% at 18mo, and 54% at 24 mo. 2) Unified Parkinson's Disease Rating Scale (UPDRS) scores with patients on levedopa were improved by an average of 38% (6 mo), 50.2% (12 mo), 69.3% (18 mo), and 73.9% (24 mo), while off medication scores showed reductions ranging from 24.7 at 6 mo to 55.1% at 24 mo. Other measures, including Hoehn-Yahr staging, Activities of Daily living, and dyskinesia rating scales, were also significantly improved following fetal transplants. Timed motor tasks (finger dexterity, supination-pronation, foot tapping, and Stand-Walk-Sit) performance also demonstrated highly significant improvements. Patient's self-rating scores indicated that the patients typically perceived substantial improvents in their condition. However, substantial variability in the improvements following surgery still persists and ranges from nominal improvements in performance to significant changes that can be classified as altering the overall lifestyle of the patients. To date, 4 of the 22 subjects were considered by the physicians to be nonresponders; that is, there were no clinically relevant improvements in these patient's conditions. I hope this helped you a bit......have a happy new year... dejana, toronto On Wed, 1 Jan 1997, Jacob Drollinger wrote: > I am currently considering having a transplant done at the U of Colorado. I > have been in contact with Dr. Freed, and have sent him, upon his request, my > MRI reports. > Brian Collins wrote to Karen Z. that the research going on in Sweden was > having great results. Can anyone tell me what, if any results are coming back > from the U.S. trials? > > Jacob Drollinger >