I am interested in your GDNF results for my Dad. Please keep me posted. My
e-mail is [log in to unmask] My snail Mail address is : Debbie Bevel
10 Cinnamon Teal Place
The Woodlands, TX 77382
I wish the best for you. GDNF seems to show great promise for the future.
It could be that the permanent catheter might not be needed later. We will
be praying for you and thinking of you often.
>I am new to the parkinsn list, a PD veteran of 6+ years, & a volunteer
>for the Amgen GDNF clinical trials which are being conducted at 6 sites
>(5 in US & 1 in Canada) In animal studies GDNF showed great promise in
>increasing the number & size of dopamine brain cells. 48 volunteers
>will be involved in the study - 8 at each site. the study is divided
>into 4 groups (called "cohorts") 12 people per cohort, 2 at each site.
> Cohorts 1 & 2 are underway. I will be in cohort 3 which begins sometime
>after Mar. 4 if all goes well. Each cohort receives a higher dosage of
>GDNF (25% received a placebo) This is a "phase 1 1/2" study, the primary
>purpose being to test the safety & tolerability of the substance so the
>amount of GDNF being injected is relatively small. I have gathered
>quite a bit of info. & will be happy to share using this forum if there
>is a lot of interest. however this will require many keystrokes fr.
>fingers not as cunning as they once were. If Joy is the only one
>needing details, perhaps a snail-mail package directly to her will do.
>KEEP IN MIND: GDNF must be injected directly into the brain; a permanent
>ICV port & catheter has to be surgically implanted in the patient's
>head.
>
>
