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On Thu 09 Jan, Joao Paulo Carvalho wrote: For: Joao Paulo Carvalho Hello Joao Paulo, I noticed that you are taking Madopar tablets, So I thought you may find the following items interesting. The chemical which is used to protect the levodopa in Madopar tablets is called Benserazide. It appears to do exactly the same job as Carbidopa does in the Sinemet tablet. There is however, one area where Carbidopa and Benserazide MAY behave differently: It is fairly well known that when taking Sinemet tablets, the function of the Carbidopa is to protect the levodopa from chemical attack as it travels through the blood stream on its way to the brain. About 70 to 100mg of Carbidopa per day is required to that job. If more than that is taken, it starts to 'protect' other Amino Acids in the blood stream, causing symptoms of tiredness and Lethargy and sometimes sickness. That, I think, is why Sinemet is available with different doses of Carbidopa There is some evidence that with Madopar tablets, the tiredness etc. symptoms do not occur, even with high doses of Benserazide. Also, Madopar do not cover a range of Benserazide content that is to be found in Sinemet IF anyone has information to support or reject the notion of there not being a 'Benserazide toxicity' problem, I would like to see it. Regards, -- Brian Collins <[log in to unmask]>