These are some results of a search. I would suggest that you use
this search engine for further information.
http://www.cyber411.com/search/
-----------------------
progressive supranuclear palsy
(Steele-Richardson-Olszewski syndome)
http://chorus.rad.mcw.edu/doc/02040.html
about 8% of patients with clinical diagnosis of Parkinson disease
median age of onset = 64 yrs (range 50-77)
core clinical syndrome
supranuclear ophthalmoplegia
akinesia (presents as frequent falls)
rigidity
nuchal dystonia
pseudobulbar palsy (dysarthria, dysphagia)
cognitive abnormality leading to dementia
imaging
atrophy of midbrain (substantia nigra) and pontine tegmentum
with abnormally enlarged prepontine cistern variable atrophy
of globus pallidus some cases show atrophy of
fronto-temporal regions with enlarged lateral ventricles and
third ventricle some cases show atrophy of motor cortex
neuropathological changes
neuronal loss and gliosis with neurofibrillary tangles
oculomotor nucleus substantia nigra basal ganglia
DDx
cortico-basal degeneration
multiple system atrophy
striatonigral degeneration
Shy-Drager syndrome
olivo-ponto-cerebellar atrophy
arteriosclerotic disease with lacunar infarction
idiopathic Parkinson disease
| CHORUS | James Lowe DM BM BS MRCPath 03/09/95 | Comment |
----------------------
Steele Richardson Syndrome info
http://dem0nmac.mgh.harvard.edu/neurowebforum/AlzheimersDiseaseArticle
s/SteeleRichardsonSyndromeinfo.html
This article submitted by [log in to unmask] on 10/20/95.
A physician caring for our grandma who has been diagnosed with
Alzheimers, mentioned the possibility of her suffering from
another syndrome, Supre Nuclear Palsy or Steele Richardson
Syndrome. I have tried a couple of search engines on the
web and gopher through the Univ/Minnesota with no luck.
If anyone can point me in the direction of research on this
I would be so grateful. It appears that this may affect the
treatment she gets, and she is hovering at death's door, in
the ICU as I write.
Please respond on this forum, or respond to my email address
"[log in to unmask]"
Thank you
Lisetta Chalupiak
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P.S.P.Site (3/13/96) 5:00 AM
P.S.P.Site
This response submitted by Tom Kelly on 3/13/96.
Author's Email:
For location for Steele Richardson Group in U.K. (Europe) Check Glaxo
Neurological Centre Web Site Url
_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/_/
_/ _/
_/ Central Supply & Services _/
_/ (Internet Training and Research) _/
_/ PO Box 57247, Jackson Stn., _/
_/ Hamilton, Ontario, Canada, L8P 4X1 _/
_/ John S. Walker _/
_/ Email [log in to unmask] _/
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