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Good Brian, Brian Collins wrote: > > On Thu 09 Jan, Joao Paulo Carvalho wrote: > For: Joao Paulo Carvalho > > Hello Joao Paulo, I noticed that you are taking Madopar tablets, So I > thought you may find the following items interesting. > > The chemical which is used to protect the levodopa in Madopar tablets > is called Benserazide. It appears to do exactly the same job as Carbidopa > does in the Sinemet tablet. > > There is however, one area where Carbidopa and Benserazide MAY behave > differently: It is fairly well known that when taking Sinemet tablets, the > function of the Carbidopa is to protect the levodopa from chemical attack > as it travels through the blood stream on its way to the brain. About > 70 to 100mg of Carbidopa per day is required to that job. If more than that > is taken, it starts to 'protect' other Amino Acids in the blood stream, > causing symptoms of tiredness and Lethargy and sometimes sickness. That, I > think, is why Sinemet is available with different doses of Carbidopa > There is some evidence that with Madopar tablets, the tiredness etc. > symptoms do not occur, even with high doses of Benserazide. Also, Madopar > do not cover a range of Benserazide content that is to be found in Sinemet > > IF anyone has information to support or reject the notion of there not > being a 'Benserazide toxicity' problem, I would like to see it. > Regards, > -- > Brian Collins <[log in to unmask]> That is Brian.Thanks for your concern. Our med here in Brazil is produced by the Roche Lab under the name of *Prolopa 250*.The tablet composition is 200 mg of levodopa and 50mg of cloridrate of benserazide. Best wishes, +----| Joao Paulo de Carvalho |------ + | [log in to unmask] | +--------| Salvador-Bahia-Brazil |------+