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On Sat 11 Jan, Ron Reiner wrote: > Joao Paulo said: > > > >Ron you say that you know the side effects of Sinemet and Permax.But how > >sure are you that the culprit was Sinemet ? Could'nt be the combination > >with Permax the reason for the side effects ? > >I tell you that because I was taking levedopa(Sinemet like) and Eldepryl > >and started to feel some funny side effects.By my own I suspended slowly > >the Eldepryl and the side effects desapeared after some time.I am no > >longer taking Eldepryl. > > > Joao Paulo: > > I appreciate that perspective. I tried Sinemet alone for awhile and > definitely know its side effects on me. I used Eldepryl alone for awhile > and know its side effects (minimal). Finally, I used Permax in conjunction > with Eldepryl. That was definitely the worst state. I wasn't on enough > Permax to be doing any good. My neuro said that he wanted to begin the > titration process at an early stage. You could be right about the > interactions but my neuro felt that Eldepryl has neuro protective effects > and I did not give up on it. So, I dropped (and blamed) the Permax. > > Because my symptoms are still mild, my Neuro and I have seen no reason to > begin experimenting with new combinations (unless he feels something is > neuroprotective). In the meantime, I am happy to sit and wait for new > treatments to appear and the medical community to gain experience with them. > > Since supplementing my diet, my handwriting has significantly improved and I > find it easier to walk. It could be the cyclic nature or PD, my > imagination, the beating I take in Hop Ki Do (martial arts) class or the > supplements. Either way, I'm happier. > > Ron Reiner > > Hello Ron. I am aware that some of you might think I have shares in Sinemet, the way that I keep plugging it, but I prefer to think of it as just being realistic. You ,Ron are doubly unfortunate, as not only do you have PD, but you have a bad reaction to the major drug in the treatment box. Now I fully accept that in the early stages, you and your neurologist have a large array of toys to play with,and there are numerous combinations of these peripheral drugs which can satisfy your requirements. The point that I feel you need to keep in mind is that you are at the start of a journey - one that will last for the rest of your life, and it is so easy to look down and worry about where your feet are treading right now, when you should be looking to the horizon, and planning your route. If you take this long term view, one drug stands out as the Only one to stay the course, and that of course is Sinemet/Madopar. Nobody is daft enough (That is somewhere between silly and crazy, Joao Paulo) to suggest that you should take let's say 7 mg of Permax plus of course your daily fix of Eldepryl, because everyone knows that the Permax would probably kill you, yet everone expects Sinemet to do the job. The message is : Sooner or later you must come to terms with Sinemet. I firmly believe that anyone can learn to tolerate Sinemet, either by gradually increasing the dose from zero, or, as Bob & Joy Graham pointed out recently, as a last resort, the anti- emetic drug domperidome ( or Motillium) will easily control the tendency to vomit. Also, just to pre-empt those who think early use of Sinemet affects its usefulness later on, wake up- you are in a a dwindling minority: It is not so. Best wishes, -- Brian Collins <[log in to unmask]>