There has been much discussion lately regarding the pros and cons of using
Amantadine in treatment of PD. I'd like to add my two cents worth and a
dime's worth from Emory Univ. - Because each PWP is unique in his/her
symptoms, reaction to drugs, lifestyles, attitudes, etc, so will his/her
response to Amantadine be equally unique. It DOES REMAIN a viable and
effective drug option for MANY PWP both in the newly diagnosed as well as in
the advanced stages of PD. Two of its' advantages are that in those who do
receive a therapeutic benefit from it usually experience few and minor side
effects - and - it is very inexpensive when compared to most of the other PD
drugs.
Because it is considered to be a an anti-colinergic, it has a drying
effect, often causing a dry mouth and constipation.
The doctors at Emory have found it to be particularly effective as
adjunct therapy with Sinemet in advanced PWP who, for a variety of reasons,
no longer receive a desireable response from the other agonist drugs
(Parlodel and Permax). It serves to enhance the effectiveness of Sinemet
while smoothing out the dyskinetic side-effects caused by the Sinemet. The
usual dosage is 200mg-400mg/day, not exceeding 400mg/day.
Again, it should be noted that because of the uniqueness of PD, the
response to each drug by each person will be very different. One should be
very careful not to judge a drug's therapeutic value solely on his/her own
therapeutic response.
Terrie Whitling 42/15
