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For Bob & Joy Graham and Dennis Greene I am afraid that I have unintentionally misled you with my story about Eldepryl. The nighttime tablet was one of two per day prescribed for me, with vague instructions to take one in the morning, and one at night. There was certainly no hint that it could cause sleeplessness or as in my case, those incredibly vivid dreams. Don't forget that at that time nobody knew about its tricky little ways. As I recall it, Eldepryl was available some time before its rise to fame, as a MAO B blocker, but it was not popular as its effect was puny compared with Sinemet, and Parlodel. (Permax was not then available). Then the story of the Drug addicts who mistakenly made and took MPTP (which blew out the entire Substantia Nigra) hit the headlines. Some neurologists began to speculate that all PWPs maybe got there by being exposed at some point in their life to MPTP, which chopped out most of their SN cells, leaving the PD symptoms to show up maybe years later. IF this speculation was true, apparently Eldepryl, taken prior to exposure to MPTP, has the ability to stop the harmful effects. It then became fashionable to prescribe Eldepryl 'just in case',which is why it was prescribed for me. I was mot enthusiastic, because while I could buy MPTP as a potential cause of PD, I found it hard to believe that it was THE cause. So when the nightmares began, that was a good enough reason for me to drop it. Maybe I am a bit paranoid about it, but I view with horror the thought that my mind - the essential me - could be changed or altered by some chemical prescribed by a specialist who maybe wasn't playing with a full deck of cards. It has happened twice to me - in a small way as described above, and much more seriously with Parlodel, which is very high on my hate list. Incidentally, the Free Radicals theory of why Eldepryl is good for you came along much later, (as far as I was concerned anyway) -- Brian Collins <[log in to unmask]>