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> Aan 13-01-97 5:48, in bericht > <[log in to unmask], elizabeth > leslie <[log in to unmask]> schreef: > > > Hello Ida (if I may call you that) > > > > > > On Sat, 11 Jan 1997, you wrote: > > > > > The question of Marge is not fully answered, I think > > > The question is not about PWP's having schizophrenia or vice versa, but > > about > > > the phenomenon that the l-dopa used by PWP's can cause some symptoms that > > are > > > similar to some symptoms of schizophrenia (hallucinations and > confusion)and > > > vice versa psycholeptica indicated for schizophrenia can not cause PD, but > > > symptoms who are like PD symptoms: bradykinesia, dyskinesia. > > > Does it make sense to say that the med's for both diseases don't arrrive > > only > > > in the disturbed place of the brain, but unfortunately as much in > > undisturbed > > > places. > > > > > > > The l-dopa used by PWP's causes to high a level of dopamine in the "schiz > > part" > > > of the brain giving "schiz." symptoms. The psycholeptica arriving > > unfortunately > > > in the extra-pyramidal system too, causing in that region a shortage of > > > dopamine and hence Parkinson like symptoms. > > > > > > I wonder if you'd say more to me about the 'extra-pyramidal system' - my > > neuro has used this term but i have very little understanding of what it > > really means. And it is obviously part of the reason why he has not > > commenced me on l-dopa yet. Which frightens me more than a little.\ > > > > What is psycholeptica? > > > > > > > The question now is whether this symmetry is in any way indicative of a > > > relationship between these diseases. > > > I asked myself something else. Some time ago PWP's suffering from light > > > intolerance was a topic on the list. Can this be caused by to a high > level > > of > > > dopamine in the retina. > > > > > > Strangely, I have just this last week or so begunto notice some light > > intolerance that is new to me, too. > > > > > > I hope this is not an intrusion. But I always read your mails with interest. > > > > Regards > > > > Beth Leslie > > > Dear Beth > > Of course you do not intrude. E-mail in general is not intruding as telephone > can be. Besides I like always to hear (read ) that anyone has seen what I > wrote. So you are very welcome. > Parkinson's disease is a disturbance of the extra pyramidal system. Our > movements are regulated by two systems the pyramidal and the extra=pyramidal. > The first regulates the whole movent that we can consciously regulate with > our > will. The second has the task of fine tuning of our movents. Movements are > initiated in the upper part of the pyramidal system. So when one is standing > and decides to lift ones arm, this decision causes activity in some place > high > in the brain which is part of the pyramidal system. To do the lifting however > is a very complex because it disturbs your equilibrium and in some way one > has > to compensate for that. One doesn't need to know all de muscles in your arm > who > all work together, to make the movement,and at the same time keep one > upright. > Our consciousness does not meddle with these things. A part of the extra > piramidal system coordinates movement with vision; by this we are able to > take > a pen from the table steering our hand exactly to the right place. That part > is > in PWP's undisturbed. > But the other task, the coordination of movements themselves, that is were PD > does his harmfull work. > If your neuro. says you have a disturbed extra-piramidal system, that is > nothing to be scared about. PD is the most frequent extra-pyramidal disease. > The most probable reason for not giving you l=dopa what I think is that he > thinks your disease is not yet that worse. Some neuro's think it is better to > postpone the l-dopa as long as possible. > Now the psycholeptica. Psycholeptica are sometimes called major > tranquilizers. > They are used by people who are psychotic, who are not able to see reality in > an ordinary way, Have hallucinations or hear voices. > The medicines against these symptoms had in the past parkinson like symptoms > as side effect. Nowadays this is less so. > I hope I answered your questions. If you want to know more feel free to ask. > > I recognised much in what you told about the neuro who couldn't stand crying. > I was some time hospitalised to be diagnosed. I did have a tough time before > > knowig I was ill but not what it was. I had to hold myself together for the > children. So being in a hospital I diminished control. All people reactred by > trying to let me stop. It was not possible to let me simple cry,because I had > reason to. > Ida Kamphuis > Holland >