I am in a study con pairing Senemet and Pramipexole. The study will last two years. I just completed week one of which ever med I am getting. Wonderful! This is the first time in eight years that I can tune one piano, much less three or four, without severe neck, back, arm, and leg pain. Only some of my symptoms are improved, but I actually exercised when I got home, and it felt good. I have no illusions about the current state of PD meds. That`s why at age 48/1/12 I agreed to be in a study group. Hope springs from a well eternal. [log in to unmask]