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There is some literature about Sinemet timing strategy, although opinions and situations vary. Try the list archives for citations on levodopa effects (e.g., Neurology, 1996, V. 46, pp 1051-1054). Also mentioned in R. Duvoisin's book: The gist is that protein competes with levodopa for absorption through the intestinal wall, therefore more of the drug reaches the bloodstream (and thence the brain) if taken on an empty stomach. Cheers, Joe J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks CA 91403