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Hi Brian Collins <[log in to unmask]>, you wrote >On Fri 17 Jan, Nigel Cockle wrote: >> I have been taking Pergolide since May last year and, having got past the >> initial side effects, I have found that it greatly improved my response to >> sinemet. In the last couple of weeks, the off periods have become much worse. I have >> read somewhere that pergolide is only effective for a limited period. Should >> I increase the dose, try not taking it for a few days or just accept that it >> will be of no further use to me? >> Nigel Cockle >Hello Nigel. >I have had quite good experience with Pergolide. >Your problem (and mine) is not the fault of the Pergolide losing its >effectiveness, it is the progress of Parkinson's in its ever- downwards >descent. Like all the Dopamine agonists, Pergolide appears to have a limited >capability to literally replace dopamine as a neuro-transmitter, and I don't >know why they are limited. > >I am due to see my neurologist in 2 weeks time and I intend to lean on him >to prescribe Re-Quip for a change. The 'theory' is that there are up to 5 >types of dopamine receptor; some are associated with dyskinesias and some >are not. The makers claim that Re-Quip homes in on receptors which do not >cause Dyskinesias, thus allowing us to take more Sinemet. I say 'theory' >because most neurologists to whom I have spoken appear to have an "I'll >believe it when I see it" attitude. Well, Ropinirole (Requip) certainly works for me - no side effects, no dyskinesias! -- Jeremy Browne - [log in to unmask] Shaking Hands BBS - +44 (0)1252 626233 - Fidonet 2:252/160