I have a question for the group about pd, My mother has an appointment with a new DR. in a couple of weeks, and I will ask him also, But, she takes only 2 1/2 sinemet CR a day,one AM, one 5 hrs.later, and the 1/2 around 6 pm. My question is, about 7 pm., she totaly runs out of energy, like a baloon with the air being let out. within minutes, she has to lay down. Is this what you are refering to as the ups and downs of sinemet?? or is it a lack of propper sinemet level? or something elce going on? any advise, thank you WHITIE