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>From one who suffered from toe/foot/leg cramps, I can only relate that there were no longer any meds available from my neuro that I could take. I was at my max limits. it was radical and I took a chance (with no promises from the neuro or surgeon) but I went into my pallidotomy in total cramp conditions. On both feet the toes were curled under, my foot to my ankle was twisted in cramp and my calf's were in a knot. I walked off the table and never had it again since. AS FOR VIT. E. I am fortunate to have the Dir. of Research and Development for PDF as my neuro. Two years ago he stressed the importance of VIT E and C. The E to help relieve the leg cramping and the C to slow down the progression of PD. Both have been verified I began to liquify my Sinemet into one litre of C each day...and I take 1600 units DI-ALPHA TOCOPHERYL ACETATE in soft gel form every A.M. and again P.M. === 320 i.u. per day. Additionally, he perscribed ATIVAN to be used as a "calming-down" help....Actually, I found that Excedrin PM worked better as a pain reliever AND it helped me get a nights sleep when taken as a sleep aid.. good luck to you all....I cry for your pain. Joyce