On Tue 21 Jan, David Langridge wrote: > <snip> > It seems strange that although I have been following the list for almost two > years I have seen no mention of this problem except in a posting from Ida > Kampuis in October and amongst many other interesting things she sais <<<< > An important difference between the two states of hyperkinesia is that the > end of meds one is combined with high muscle tension end the other much less > so. This makes the former the most troubling one. During the former walking > is more impaired or impossible.>>>>. As mentioned above I have experienced > this end of meds muscle tension.Also I have searched in the archives and > found no mention of diphasic dyskenesia the only hit being the algorythm > paper which I already had read. > <snip> > I think I have tried about everything to deal with the problem -sinemet with > and without cardidopa, sinemet CR , halving tablets and taking at shorter > intervals, no protein diet,pergolide (good), ropinoprol( not so good seems > to make the dyskenesia worse) The only other regular drug for me is > Seleginin twice a day and I've even tried knocking that out to see if it > makes any difference. ><snip> All of which brings me to some final points; > > 1. I can find no explanation of how this end of dose overdosing occurs.What > is the mechanism? > > 2. How does all this tie up with the theory expounded so admirably by Brian > Collins that the therapeutic window narrows with progress of the disease. I > don't regard myself as far progressed in pd yet as soon as I started on > Sinemet I began to experience the overdose effects aslbeit not during the > "on" and this indicates to me that problems with sinemet do not always arise > just through narrowing of the theraputic window due to progression of the > disease. > > Any input would be gratefully received (Back to Basics has my support) > > David Langridge > ========================================================================= If you will forgive me for blowing my own trumpet a little, David, there is one major thing that you have not done, and that is to make use of my analysis program !! If I cast my mind back a few years when I was beginning to hatch the concept of the program, I was just like you - casting around desperately trying to find some sort of formula which would control my symptoms. It became obvious that I was trying to keep too many balls in the air at the same time; there was too much going on. Like any Engineer, I decided that the only option was to write a program, so I did. Bear in mind that my concept of the vanishing window (the notorious charts A & B ) were just a twinkle in my eye at that stage. It is obvious to me now where I went wrong - Instead of phrases like 'diphasic dyskinesia', I tend to refer to 'that lump on the graph'. It doesn't have the same resonance somehow does it. All I can tell you is that it worked for me. There are two reasons why I introduced the program to the list: 1) To get a wider sample of people to try the system, and hopefully show that it can cope with a wide range of symptoms. 2) Because it was clear to me from the questions which were being asked through the list that there was a need for something like this. Now I come to the sad bit. Out of the scores of people who took my write-up enthusiastically, bombarded me with questions , and generally encouraged me to think that I was providing a much-needed service, only 5 (yes Five) people actually followed thruogh to the point of sending me data that I could analyse. I am distressed and puzzled at this strange failure to follow through to the end point. All you folk out there with the red ears know who I mean, and I am sure that you have good reasons why you dropped out. Was it my write-up? was it too technical / not technical enough, or maybe too demanding of your time ? I think it was you, David, who said something about it being better to get out and live your life rather than worry about details, so I guess that make me the ant, and you the grasshopper. (It has just occurred to me that the Internet Suite which I use with my Acorn RiscPC is written by a company called ANT software. That must mean something!! Just on the vague chance that anyone is interested, the URL to go to on the web to find a full write-up of the program is: http://www.ridgecrest.ca.us/~rfvetter/brianspd.html If you get no response, split the URL in two: Go to http://www.ridgecrest.ca.us/ - This gets you into the site. Then go to ~rfvetter/brianspd.html This finds my page. Regards -- Brian Collins <[log in to unmask]>