Linda, Please remember I am not a doctor, only a PD patient (63/7) willing to help; You wrote : "What, in your opinion, are the "hallmark" signature symptoms of PD? ". All PD's are different. A PD patient does not have the same symptoms than another patient. Symptoms also vary within minutes, or slowly over years. Symptoms are closely interlinked with emotions. As far as I know, there is no such thing as a scientific test leading to a diagnosis. The only clues we have to make sure whether somebody has PD are the following : - Visit several neurologists - Ask several PD patients - Watch the effect of levodopa : if it works, it is probably PD. Try a pause (under medical control) : you will see what happens You also wrote : "Seriously, I question my husband's diagnosis, yet cannot get him to get a 2nd opinion". This sounds like another disease, which is refusing to face a stressful situation. This second disease can be devastating if your husband does not want to double-check the first diagnosis : if he really has PD, he will lose a lot of the energy he needs to fight against the disease ; if he doesn't have PD, his medical treatment is unnecessary, if not dangerous And don't forget to take care of yourself. He needs you to stay in good shape. Bernard [log in to unmask]