I have been following this list for sometime but have never posted to it because everything I have to say is covered more ably than I could. However the message from David Langridge concerning diphasic dyskinesia hit home. After being diagnosed with PD about 8 years ago this symptom started for me a year ago - and at times drives me batty (g). I had always thought dyskinesia happened when there was too much dopamine was released in your brain but this definitely happens at the end of dose time. My muscles get rigid from trying to stop moving and I ache all over. This dykinesia does not seem to noticed by others but I feel I am going to squirm out of my chair. Like David I too have tried all sorts of schedules with sinemet -just when I think I have it solved I don't Brian I read your message and have copied it so I can read it when I have time. I still work full time, am my own caregiver, get depressed, have trouble sleeping and all the other lovely symptoms that accompany PD but am also very thankful for the things I can do. ***************************************************** Rosemary Paul [log in to unmask] Community Services x3919 *****************************************************