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Dennis... Prior to my unilateral pallidotomy on Oct. 24, 1994, I began falling a sleep briefly in the evenings for about 1/2 an hour - more a dozing in and out of sleep. It made no difference if I was busy with an activity or not, either.... Just up and fell asleep! Post pallidotomy, I've noticed periods of profound fatigue (not sleepiness, but an overwhelming TIREDness) beginning about 4-ish p.m. almost daily. At that time my feet feel like they're freezing cold. If I put a heating pad on my feet and relax with a blanket over my body (warming up pretty fast), the fatigue passes in about an hour or so. However, if I DON'T do this (and I don't always do it because I might be working, or away form home), I am practically guaranteed of falling asleep later in the early evening no matter WHAT I'm doing or who I'm with at the time. Very embarrassing if I'm on a date or have company over! I take my meds as follows: 11 - 12 am = 1/2 generic Sinemet 25/250, 1/2 20 mg. Paxil, 1 multi-vitamin/mineral tablet, 800 ICU vitamin E. 12 noon to 1-ish pm = Sinemet CR 25/200 (might be 50/200 - can't remember off the top of my head) NOTE: The above is ALWAYS taken with ginger ale (for medicinal reasons)and I eat no food till about 1 to 2 pm, depending upon the time I first take the drugs. 5 to 6 pm = 1/2 generic Sinemet 25/250 and 1 Sinemet CR 25/200 Occasionally 1/2 generic Sinemet 25/250 about 10 or 11 pm if I've still got more typing to do or am out for the evening. And that's it. Hope this helps to construct the picture you're trying to build, Dennis. Barb Mallut "Lil_Honey" on the PD Chat [log in to unmask] ---------- From: PARKINSN: Parkinson's Disease - Information Exchange Network on behalf of Dennis Greene Sent: Thursday, January 23, 1997 3:51 PM To: Multiple recipients of list PARKINSN Subject: Sleepy time. Help!! I am looking for information on the habit some of us have of falling asleep as our meds 'kick in'. I am not talking about falling or giddyness due to hypotension. I AM talking about sleep associated with the relaxing of the muscles as we move from OFF to ON. I would be most interested to hear from PWP who have exprenced this reaction and have had a pallidotomy. I have already accessed the archives where a 60 page search result yeilded only six relevent items. With this in mind would anyone responding to this message do so through the list so that we can add to that body of information. Thanks in anticipation, Dennis ++++++++++++++++++++ Dennis Greene [log in to unmask] ++++++++++++++++++++