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Very good, Mary Ann, Bent Willow wrote: > > This report was sited in Chem and Engineering news (12/16/96). My husband, > Jamie, thought list members might be interested. > +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ > > Pyridostigmine, a drug that protects against the effects of organophosphate > chemical warfare agents, crosses the blood-brain barrier in mice under > stress *much more easily* than it does in unstressed animals, according to > a study by Israeli researchers (Nat.Med.,1 1382 (1996)). The findings may > explain an earlier report that Israeli soldiers serving in the Persian Gulf > War were three times more likely than expected to show central nervous > system side effects of the drug. Some U.S. soldiers also received the > drug. A carbamate inhibitor of acetylcholinesterase, the drug is > quaternanry ammonium compound that would not be expected to pass through > the tightly packed layer of endothelial cells that normally keep lipophobic > molecules out of the central nervous system. However, Alon Friedman and > Hermona Soreq of Hebrew University in Jerusalem, Ilan Tur-kaspa of > Tel-Avivi University's Sackler School of Medicine, and their colleagues > find that mice that are stressed by being forced to swim require only 1/100 > the dose of unstressed mice to inhibit a comparable level of > acetylcholinesterase in their brains. If this effect turns out to be a > general one, the researchers suggest, "these alterations in blood-brain > permeability might have far-reaching clinical implications." > +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ > > Many participants on this list have suggested that stress has had an impact > on their PD symptoms and medication effectiveness. One wonders if testing > has been done to determine how stress impacts on the metabolism of Sinemet? > --------- > Regards > Mary Ann This I suspected since I observed that taking levodopa early in the morning and before playing a competitive sport such as soccer, I noticed that during the rest of the day I felt as there was a better improvement in my general well being and from the sligth or mild tremors in the rigth hand or thumb. Best wishes, +----| Joao Paulo de Carvalho |------ + | [log in to unmask] | +--------| Salvador-Bahia-Brazil |------+