Henry G.. I know Vicodin is for pain, and cannot take it without a negative reaction vis a vis the PD symptoms becoming extreme. AND, when my MD prescribed it, and I reminded his that I have PD, he commented, "Vicoden won't affect THAT." W R O N G!! VERY wrong... Henry... I don't know what a lotta the meds your wife is on are for, but surely she can be carefully and slowly weaned off one, then another and yet another till the negative aggressiveness hopefully disappears or lessens, and can thus indicate what the cause of that aggression might be - or NOT be? Keep in mind that while there's a good chance it MAY indeed be caused by one o f a combination of he drugs, it may also just be where she's at in life (I know, m'dear... that is NOT what you'd prefer to hear!). Or, it may mean that she's going thru a neurological crisis as yet to be identified. One last thing, Henry... and I mean no insult to your intelligence or level or caring in saying this, but have you been able to just sit down with your wife in one of her calmer moments (IF there are any), and TALK to her about her becoming aggressive? Maybe ask her what SHE thinks might be the cause, IF she's even aware of the situation? Errrrr... obviously this won't work at all if she's become some kind of raging amazon-with-PD! I'm rootin' for you and your misses, Henry.... Barb Mallut "Lil_Honey" on the PD Chat [log in to unmask] ---------- From: PARKINSN: Parkinson's Disease - Information Exchange Network on behalf of Henry Guttentag Sent: Monday, January 20, 1997 8:20 PM To: Multiple recipients of list PARKINSN Subject: Help needed re-medication TO ALL MEMBERS: I HAVE HAD PROBLEMS WITH MY WIFE WHO HAS HAD PD FOR AT LEAST 8 YEARS. HER PERSONALITY HAS TOTALLY CHANGED TO THE POINT FROM PASSIVE TO VERY VERY AGGRESSIVE. I AM WONDERING NOW IF THE MEDICATION IS NOT PLAYING HAVOC WITH HER. SO I AM REQUESTING IF ANYBODY HAS HAD BAD EXPERIENCES WITH ANY OF THE MED. COMBINATION SHOWN BELOW. I WOULD APPRECIATE YOUR INPUT. THE DOCTOR (NEUROLOGIST) DOES NOT THINK SO, BUT I BELIEVE THAT HE MIGHT BE WRONG. SHE SHOULD BE ON SINAMET HOWEVER SHE CLAIMS TO HAVE SIDE EFFECTS FROM THE MEDICATION,SO THE DOCTOR HAS KEPT HER ON ARTANE?? MEDS SHE TAKES: ARTANE, EFFEXOR, ATIVAN,VICODIN, LODINE, RISPERDAL AND PANCREAS I THANK YOU HENRY GUTTENTAG ([log in to unmask])