Please let me help with this medical research.
Look for the stars they are my comments.
>I believe the nicotinomide (sp??) that we find in the long name for =
NADH
>refers to a B vitamin, I think a form of niacin, hence the prickly h=
eat and
>flush response. Not related to nicotine, pretty sure.
>Kathie Tollifson
>[log in to unmask]
>46/8
TI: Efficient reduction of lipoamide and lipoic acid by mammalian thi=
oredoxin r
AU: Arner-ES; Nordberg-J; Holmgren-A
SO: Biochem-Biophys-Res-Commun. 1996 Aug 5; 225(1): 268-74
PY: 1996
AB: Reduction of the antioxidant lipoic acid has been proposed to be =
catalyzed
in vivo by lipoamide dehydrogenase (LipDH) or glutathione reductase (=
GR). We
have found that thioredoxin reductase (TR) from calf thymus, calf liv=
er, human
placenta, and rat liver efficiently reduced both lipoic acid and lipo=
amide with
Michaelis-Menten type kinetics in NADPH-dependent reactions. In contr=
ast to
LipDH, lipoic acid was reduced almost as efficiently as lipoamide. Un=
der
equivalent conditions at 20 degrees C, pH 8.0, mammalian TR reduced l=
ipoic acid
**** This is an important sentence, the NADH is for sale and it is so=
mewhat
effective, well really effective for my father, his legs (as he told =
me=20
loosened up) the NADPH is 15 times more effective than NADH, let me s=
top here
the nicotine has nothing to do with NADH, OK, What the nicotine does =
is turn
on a receptor in the brain, it has something involvement with the Chr=
omosome
15, now for the NADH, remember that the NADH is simply nothing more t=
han a=20
enzyme, and in some people this enzyme is deficient, this enzyme work=
s in the
body to make dopamine, so this is something that we already know we n=
eed.
When our body is not making enough of this neurotransmitter(dopamin=
e).
We need something to give it a boost kind of like Vitamin C. Then thi=
s medical
research tells us that better than NADH or NADPH there is this Thioch=
ic Acid=20
that is 2.5 times better than the NADPH. So I have up-graded my comp=
uter, and
I am trying earnestly to find more information on this Thiochic Acid,=
that=20
I believe is safe, but I need to learn more about it. I am 42 years o=
ld and=20
I will not rest until I have found a way to get my father out of this=
, so
hang tight, I am looking out for a cure! Mean while, change your diet=
, nothing
processed, nothing canned(aluminum) change your shampoo and toothpast=
e, again
aluminum, the Lord said that Bread was the staff of live, well read y=
our
history, bread was made by whole grain Quinoa, not your average off t=
he=20
counter bread, so check! Now, amino acids like methionine and phenyla=
lanine,
get this book called Thorsons Guide to Amino Acids by Leon Chaitow, y=
our
doctor is not going to tell you this because there is no profit in na=
tural
medicine, now a Hair Analysis is a good idea, it showed me what nutri=
ents=20
my father was deficient in. (but it costs). What you probably have no=
t been
told is althought you may be taking vitamins that your body is not ab=
sorbing
them, this is why you need digestive enzymes, if your body was taking=
in these
nutrients from food then you probably would not have parkinsons disea=
se,
so then you need to enforce detox, now I probably have everyone confu=
sed.
But this is the road to getting well. It is really not that hard, and=
I am
willing to help anyone that needs to get started. You could visit you=
r health
food store and show them this letter and they will understand what yo=
u need.
1)get the NADH for now
2)ask for digestive enzymes
3)get a hair analysis to see where the problems are
4)eat complex-carbohydr. they are easy for the body to break down.
I will try to post more tomorrow. you can e-mail me at carltonl@citad=
el.edu
Best Wishes Linda Forrests Mom
by NADPH 15 times more efficiently than the corresponding NADH depend=
ent
reduction catalyzed by LipDH (297 min-1 for TR vs. 20.3 min-1 for Lip=
DH).
Moreover, TR was 2.5 times faster in reducing lipoic acid with NADPH =
than in
catalyzing the reverse reaction (oxidation of dihydrolipoic acid with=
NADP+).
In contrast, LipDH was only 0.048 times as efficient in the forward r=
eaction as
compared to the reverse reaction (using NADH and NAD+). We conclude t=
hat all or
part of the previously described NADPH-dependent lipoamide dehydrogen=
ase
(diaphorase) activities in mammalian systems should be attributed to =
TR. Our
results suggest that in mammalian cells a significant part of the
therapeutically important reduction of lipoic acid is catalyzed by th=
ioredoxin
reductase.
P, Marsden CD. Biochem Pharmacol 1996;51:983-986.=20
Nigral cell death in Parkinson's disease is associated with decreased
reduced glutathione (GSH) levels, impaired complex I activity and inh=
ibition
of alpha-ketoglutarate dehydrogenase (alpha-KGDH) in substantia nigra=
.
Thioctic acid exerts antioxidant activity through a thiol-disulphide =
redox
couple and is an essential cofactor for alpha-KGDH. However, it is no=
t known
whether or not thioctic acid enters basal ganglia or exerts beneficia=
l
effects in Parkinson's disease. As a global measure of altered cerebr=
al
function, the effect of R- and S-thioctic acid on 14C-2-deoxyglucose
(14C-2DG) incorporation was investigated in rats. Rats were treated w=
ith
either R- or S-thioctic acid (50 mg/kg IP) or 0.9% saline acutely or =
for 5
days and 14C-2DG incorporation in basal ganglia was assessed. Followi=
ng
acute administration, R- but not S-thioctic acid caused an overall in=
crease
in 14C-2DG incorporation that was significant in both substantia nigr=
a zona
compacta and zona reticulata. R-thioctic acid also increased the
incorporation of 14C-2DG in the medial forebrain bundle, thalamus, an=
d red
nucleus. S-thioctic acid decreased 14C-2DG incorporation in the subth=
alamic
nucleus, but increased it in the red nucleus. Following repeated
administration, R-thioctic acid no longer increased 14C-2DG incorpora=
tion in
either zona compacta or zona reticulata of substantia nigra. However,=
both
R- and S-thioctic acid now decreased 14C-2DG incorporation in the
subthalamic nucleus. The data suggest that thioctic acid does enter t=
he
brain and can alter neuronal activity in areas of the basal ganglia
intimately associated with the motor deficits exhibited in Parkinson=
=D5s disease.=20
