Carol Brow..... Carol, you might try adding in vitamin E to your mother's regimen. It's brought many of us quite a bit of relief from nite-time toe/leg cramping... I take 2 400 ICUs ('cause the 800 ICU size is too hard for me to swallow) of vitamin E with my first Sinemet of the day, and rarely get toe/leg cramping any more. IF I should get a cramp, I just add in an additional 400 ICUs for a week, and the durn cramps disappear once again for months at a time. Barb Mallut "Lil_Honey"on the PD Chat [log in to unmask] ---------- From: PARKINSN: Parkinson's Disease - Information Exchange Network on behalf of Carol L. Brow Sent: Sunday, January 26, 1997 10:03 AM To: Multiple recipients of list PARKINSN Subject: leg cramps I am caregiver to my mother who is 87. Besides PD, she has osteoporosis and has suffered through three compressed vertibrae. She has taken supplemental calcium most of her adult life but increased the amount after experiencing the first v. compression. She takes 1500 mg of calcium with magnesium everyday. On the odd night that she wakes up with muscle pain, I give her 500 mg. additional calcium and in a few minutes the pain is gone and she can get back to sleep. Next time she has muscle pain I'll try heat while I prepare the calcium. (she can not swallow the capsules so I open them and mix them with apple sauce or something simular. I know the calcium works. I believe that there must be an increased need for the mineral at least in her case. I have used it for minstral cramps and leg cramps and it was the first thing I thought of when she first began to experience these night time leg cramps. Carol Brow Lake Leelanau, Michigan and Winter Haven, Florida