Joao Paulo, I don't know about the status of other supplements, but Thioctic Acid (aka Alpha Lipoic Acid) is being heavily researched. I have found numerous Medline abstracts describing its effectiveness as an anti-oxidant (also a chelater of iron and an inducer of glutathione production). One abstract published here on the list documented a study which demonstrated that Thioctic Acid makes its way to the substantia nigra (in rats anyway) and specifically relates this function to effectiveness in treating Parkinson's. I personally stumbled on TA on a research web page at Berkeley. The big problem is that no one claims that TA mitigates the symptoms of PD. If anything, it is an anti-oxidant which might delay the progression. I assume, as a powerful anti-oxidant, TA will also reduce the chance of spontaneous combustion in PD patients taking it. The only "research" I have stumbled on for NADH is the oft quoted Birkmayer (sp?) study. We have all witnessed the vitriolic discussions concerning NADH on this list. I have heard many medical/biology professionals dismiss it for any number of reasons. Some say it can't do any good but can have serious side-effects. Others say it is so active, it will be chemically neutralized before it reaches the stomach. Someone else said that our bodies are already so full of NADH that it would take a truckload to have any real effect. Please note the contradictory observations. On the other hand, you have the "pushers" trying to make a buck off of it. Finally, you have the pharaceutical companies who will do their best to quash any research in these areas. So where does all this leave us poor sufferers? It leaves us with each other communicating our personal experiences over the web. Frankly, I trust the personal experiences of PD'ers on this list more than I trust researchers. What it finally boils down to is SNEAKERS. I remember reading a newpaper column many years ago in which the journalist (someone like Dave Barry) summed up his opinion of the health research community in one word - SNEAKERS. As a child, he was forced to wear shoes all the time because the medical community predicted dire consequences to children allowed to wear sneakers (no arch support) for long periods. Apparently God forgot to give us arch supports. These same researchers were pushing the use of XRay machines at shoe stores to assess proper fit. Everytime he finds himself on the verge of accepting some fad prediction - the journalist pinches himself and says SNEAKERS! Ron Reiner At 12:28 PM 1/26/97 -0500, you wrote: >If so,then comes my question what intitutions such as NIHC,the Harvad >Neurological Center,the Mayo Clinic,The Stanford U. Medical R.,and many >others renowned research centers in USA,Canada,England,Israel and Europe >have to say on the subject.Should'nt it deserved the greatest attention >from them if the results are as told ? >