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Greetings to all Mon. I went to the neuro for a check up and he wanted to start me on Permax (Pergolide Mesylate) and lower my Sinemet to 25/100 CR. to get rid of calf and fore arm muscle spasms. I took 1 - 0.05 mg tablet and 1 1/2 hrs later I was bent over the "throne". After that I headed to bed and I had severe tremors of my whole body lasting about 45 min. also experienced some insomnia. I called the neuro and he told me that about 5% of PWP are unable to take Permax. He said he didn't want to mention it at my appt. so I wouldn't react to it just because it was possible. (he did give me samples to start with so I'm not out any money :-) ) My question is being a dopamine agonist, is it likely that such a reaction will occur with other agonists ? Or is it just to this one formula? Jon Meyer 40/1 ([log in to unmask]) another Hoosier