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31 Jan 1997 Pat, I see your fatigue symptom very often on the PD list- though I can't find it in any of the "standard" literature. As a LAYMAN'S opinion, in my own case it seems to be a sign of undermedication. I think dopamine has an important role in the peripheral nervous system, and when it is deficient, all your muscles ache from overload of lactic acid, the product of physical exertion. (Comment from any of the professionals who see this would be most welcome.) I find that shortening the interval between Sinemet dosage (normally 50mg about every 3 hours) so that an extra dose can be worked in, relieves the problem, so I can return to my regular schedule. This tactic is effective for me, especially after a session of heavy yard work or the like. I also notice that the fatigue is usually accompanied by mood depression, which goes away when the minimum tolerable dopamine level is restored. Cheers, Joe J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks CA 91403 On Fri, 31 Jan 1997 [log in to unmask] wrote: > J. and other PDers, > > Have I missed something on the way through Parkinson's? I am so tired, > fatiqued, can hardly move, stiff, etc. I feel tired when I go to bed, tired > when I get up, tired after a small exertion ( getting breakfast, feeding the > cats, dressing). What is happening? I've been told my muscles are all > fighting one another. Can someone explain what is going on? I've only been > diagnosed for two and a half years. No one ever mentions the exhaustion that > I feel or was I supposed to expect that as a given. > Oh by the way, Happy New Year. And for all you Buckeye Fans out there, > wasn't that a great Rose Bowl? > Thanks for any comments sent my way. I'm going to go rest, I'm really tired. > > Patricia of [log in to unmask] >